2-Bromoethanol → HCID 86754526, compound

Participants

Reaction Steps

N,N'-bis[2,4,6-triiodo-3,5-bis(2,3-dihydroxypropylaminocarbonyl)phenyl]-urea (2.0 g, 1.4 mmol) was dissolved in water (13 ml) containing 2M NaOH (7 ml). 2-Bromoethanol (1 g, 8.4 mmol) was added and the mixture was stirred at ambient temperature for 60 h, treated with a strongly acidic ion exchange resin (Amberlyst 15) evaporated and purified by preparative HPLC. Yield: 1.45 g (70%) of the product as a white solid. 1H NMR (DMSO-d6): 9.10-9.38 (m, 1H, NH), 7.90-8.65 (m, 4H, NH), 3.02-3.91 (m, 24H).

Provenance & Evidence