Potassium Hydroxide → 2-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid

HRID 61894Notes

Reaction equation

HRID 61894 reaction equation
C([O:3][C:4](=[O:16])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[N:9]=1)([CH3:7])[CH3:6])C.[OH-].[K+]>CO>[CH3:15][O:14][C:10]1[N:9]=[C:8]([C:5]([CH3:7])([CH3:6])[C:4]([OH:16])=[O:3])[CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 668349252-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester

Product 1

HCID 668349942-(6-Methoxypyridin-2-yl)-2-methylpropanoic acidYield 76.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester (5.33 g) was dissolved in methanol (200 ml), added with 5 N aqueous solution of potassium hydroxide (25 ml), and then stirred under reflux. The reaction mixture was concentrated and neutralized with 2 N hydrochloric acid. The precipitated matters were collected by filtration and dried to obtain the title compound (3.55 g).

Workup

  1. temperatureunder reflux
  2. concentrationThe reaction mixture was concentrated
  3. filtrationThe precipitated matters were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-68ac0fb7778f4719bde87654e031adc3
Source dataset
uspto-grants-2016_09
Patent number
US09440922B2

Reaction notes

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