Acetic Anhydride → 3-Acetoxymethyl-5-(2,3-diacetoxypropylaminocarbonyl)-2,4,6-triiodoaniline

Beteiligte Stoffe

Reaktionsschritte

3-Hydroxymethyl-5-(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodoaniline (1.32 g, 2.1 mmol) was dissolved in pyridine (10 ml) containing acetic anhydride (10 ml). The mixture was stirred at room temperature for 2 h and CH2Cl2 (100 ml) and the solution was washed with water (3×25 ml). The organic phase was washed with water (3×50 ml) and a saturated aqueous solution of NaHCO3 (2×50 ml). After drying (Na2SO4) and evaporation, the residue was purified by flash chromatography on a silica column using a mixture of CH2Cl2 and methanol (95:5) as the eluent. Yield: 1.30 g (82%).

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