1,4-Dioxane hydrochloride → (R)-alpha-methylthiomethylbenzylamine hydrochloride

HRID 618955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 618955
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][S:24][CH3:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH3:25][S:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

3

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54275246N-tert-butoxycarbonyl-(R)-alpha-methylthiomethylbenzylamine

Produkt 1

HCID 70345754(R)-alpha-methylthiomethylbenzylamine hydrochloride

Versuchsvorschrift

A solution (35 ml) of 4-N HCl/dioxane was added to 2.65 (10.0 mmols) of N-tert-butoxycarbonyl-(R)-α-methylthiomethylbenzylamine, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure, and the residue was concentrated with the addition of 30 ml of ether to obtain (R)-α-methylthiomethylbenzylamine hydrochloride in a quantitative yield.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. concentrationthe residue was concentrated with the addition of 30 ml of ether

Quellen und Nachweise

ORD-Eintrag
ord-cef5befd254e4349a648dd3a5b89cb5c
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05958496

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