Acetic Acid → HCID 15885012, compound

Participants

Reaction Steps

Compound (7) is treated with a mixture of acetic anhydride, acetic acid and sulfuric acid at room temperature, thereby to effect simultaneously the removal of the 3-O-tert-butyldimethylsilyl group, demethylation and di-O-acetylation reactions, affording 1,3-di-O-acetyl-2,4,6-trideoxy-2-fluoro-4-(trifluoroacetylamino)-L-mannopyranose [Compound (8)] having the following formula ##STR15## The Compound (8) is a mixture or α-anomer [Compound (8-a)] and β-anomer [Compound (8-b)]. When Compound (8) is subjected to a silica gel column chromatography as developed with dichloromethane, the α-anomer [Compound (8-a)] and the β-anomer [Compound (8-b)] can be isolated from each other.

Provenance & Evidence