反应详情

Mixture of 7-methoxy-3-(3-methoxymethoxy-pyridin-4-yl)-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (Compound GT15-8, 430 mg) and 4 N hydrochloric acid dioxane solution (5 ml) was heated and stirred at room temperature for 1.5 hrs. The reaction mixture was neutralized with 2 N aqueous solution of sodium hydroxide. The resulting mixture was extracted with the mixture of DCM and MeOH (DCM:MeOH=9:1). The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM/MeOH) to obtain the title compound (280 mg, 75%).

1. temperaturewas heated
2. extractionThe resulting mixture was extracted with the mixture of DCM and MeOH (DCM:MeOH=9:1)
3. customThe residues obtained
4. concentrationafter concentration under reduced pressure
5. customwere purified by silica gel column (DCM/MeOH)