5-Methoxyindan-1-one → Cis-2-[4-(2,3-dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]-5-methoxyindan-1-ol

HRID 619108Notes

Reaction equation

HRID 619108 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:16][CH2:15][N:14]([C@H:17]4[CH2:25][C:24]5[C:19](=[CH:20][C:21]([O:26][CH3:27])=[CH:22][CH:23]=5)[C@H:18]4O)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3][CH2:2]1.C[O:30]C1C=C2C(=CC=1)C(=O)CC2>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:12][CH2:13][N:14]([C@H:17]4[CH2:18][C:19]5[C:24](=[CH:23][CH:22]=[C:21]([O:26][CH3:27])[CH:20]=5)[C@H:25]4[OH:30])[CH2:15][CH2:16]3)[C:5]=2[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 787875-Methoxyindan-1-oneHCID 15860117Cis-2-[4-(2,3-dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]-6-methoxyindan-1-ol

Product 1

HCID 15860119Cis-2-[4-(2,3-dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]-5-methoxyindan-1-ol

Procedure

Prepared in the same manner as the compound of Example 1, but using 5-methoxyindan-1-one instead of 6-methoxyindan-1-one in Step 1.

Sources & evidence

ORD record
ord-53232805114e4335b38294ae685ddb0f
Source dataset
uspto-grants-1999_09
Patent number
US05958927

Reaction notes

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