Hydrochloric Acid → HCID 21846057, compound

Participants

Reaction Conditions

Reaction Steps

0.22 ml (1.58 mmol) of triethylamine is added to a suspension of 0.365 g (1.51 mmol) of 6-cyano-1-methyl-2-oxo-1,2-dihydro-4-quinolineacetic acid in 10 ce of tetrahydrofuran at -10° C., and 0.16 ml (1.6 mmol) of ethyl choroformate is then added dropwise. After stirring at -10° C. for 45 minutes, the reaction medium is filtered and the solids are rinsed with 3×8 ml of tetrahydrofuran. 0.25 g (6.61 mmol) of sodium borohydride and then 0.94 ml of methanol are added to the filtrate at 5-10° C. After stirring at 5-10° C. for 2 hours, 13 ml of 1 N aqueous hydrochloric acid solution are added. The mixture is extracted with is dichloromethane and then with ethyl acetate. The organic phases are dried over sodium sulphate and then concentrated under vacuum.

Provenance & Evidence