反应详情

温度

100 °C

To 7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (Compound A2, 2.5 g), 3-bromo-4-chloro-pyridine (2 g), sodium t-butoxide (3 g), Pd2dba3 (476 mg), and S-Phos (512 mg), toluene (20 ml) was added, and the mixture was stirred and heated at 100° C. overnight under nitrogen atmosphere. After cooling, the reaction mixture was diluted with ethyl acetate and filtered through Celite. The organic layer was washed with saturated aqueous solution of sodium bicarbonate and saturated brine. Thereafter, the organic layer was dried over sodium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column (ethyl acetate/hexane) to obtain the title compound (112 mg, 4%).

1. temperatureAfter cooling
2. filtrationfiltered through Celite
3. washThe organic layer was washed with saturated aqueous solution of sodium bicarbonate and saturated brine
4. dry with materialThereafter, the organic layer was dried over sodium sulfate
5. customThe residues obtained
6. concentrationafter concentration under reduced pressure
7. customwere purified by silica gel column (ethyl acetate/hexane)