219806-93-6 → HCID 11123147, compound

Participants

Reaction Steps

A mixture of 1.9 g (7.09 mmol) of α-bromo-2,6-dichlorophenyl-acetaldehyde and 1.78 g (6.45 mmol) of (RS)-1-[4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]ethanone in 50 ml of tetra- hydrofuran was stirred at RT for 65 h. Subsequently, the mixture was cooled to 0° C. and the precipitated solid was filtered off, dissolved in 75 ml of conc. acetic acid and heated at reflux while stirring for 8 h. The reaction mixture was concentrated and the residue was purified by column chromatography on silica gel (dichloromethane/methanol 95:5). There were obtained 1.95 g (68%) of (RS)-1-[2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]ethanone as a yellow foam.

Provenance & Evidence