Diethyl Ether → HCID 21846123, compound

Participants

Reaction Steps

1.95 g (4.38 mmol) of (RS)-1-[2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]ethanone were dissolved in 20 ml of methanolic hydrochloric acid solution (2.6N) while stirring and treated with 100 ml of diethyl ether. After 1 h the crystals were filtered off. There were obtained 1.54 g (73%) of (RS)-1-[2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]ethanone hydrochloride as a beige solid with m.p. 165° C.

Provenance & Evidence