Diethyl Ether → HCID 86754542, compound

HRID 619126Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[S:31][C:12]2=[N:13][C:14]([CH3:30])=[C:15]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3OC)[N:11]2[CH:10]=1.[CH2:32]([O:34]CC)C>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[S:31][C:12]2=[N:13][C:14]([CH3:30])=[C:15]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:16]([C:17]3[CH:22]=[CH:21][C:20]([O:34][CH3:32])=[CH:19][CH:18]=3)[N:11]2[CH:10]=1

Participants

Reactant 2

HCID 3283Diethyl Ether

HCID 15392100HCID 15392100, compound

Product 1

HCID 86754542HCID 86754542, compoundYield 79%

Procedure

1.82 g (3.83 mmol) of ethyl (RS)-2-(2,6-dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate were dissolved in 20 ml of methanolic hydrochloric solution (2.6N) while stirring and treated with 100 ml of diethyl ether. After 15 h. the crystals were filtered off. There were obtained 1.55 g (79%) of ethyl (RS)-2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate hydrochloride as a light yellow solid with m.p. 233° C.

Workup

filtrationAfter 15 h. the crystals were filtered off

Sources & evidence

ORD record: ord-f5104b4141d445ef816aa674d6419a5b
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05958931

Reaction notes

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