反应详情

温度

90 °C

Mixture comprising 2-(2-bromo-4-methoxyphenyl)-propan-2-ol (100 mg), 2,3-benzofuran (0.19 ml) and polyphosphoric acid (1 g) was stirred and heated at 90° C. for 30 min. The reaction mixture was added with water and extracted with DCM. The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM/hexane) to obtain the title compound (143 mg, 51%).

1. extractionextracted with DCM
2. customThe residues obtained
3. concentrationafter concentration under reduced pressure
4. customwere purified by silica gel column (DCM/hexane)