HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 5-amino-1-tert-butyl-1H-pyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-amino-1-tert-butyl-1H-pyrazole-4-carbonitrile | HCID 2797454 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-amino-1-tert-butyl-1H-pyrazole-4-carboxamide | HCID 21846075 | 75.1% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a mixture of water (500 ml) and 85% KOH (37.91 g) at 0° C. was added 30% H2O2 (49.4 ml, 483 mmol), followed by 1-tert-butyl-5-amino-1H-pyrazole-4-carbonitrile (15.83 g, 96.5 mmol). The reaction mixture was stirred for four hours at 0° C. and then at room temperature for 1 hour. A yellow precipitate had formed which was collected by filtration and air dried to afford 13.2 g (75%) of 1-tert-butyl-5-amino-1H-pyrazole-4-carboxamide, m.p. 193-195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958929 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-7dd37e6968a04d79bfb8c22cb5868353 |
| Source note | uspto-grants-1999_09 |