反应详情

温度

-7 °C

8 ml of ammonium hydroxide, 1.58 g of ammonium chloride and 1.23 g of sodium cyanide were successively introduced and the solution obtained was cooled in an ice/methanol bath at about -7° C. 2 ml of tetrahydro-4H-pyran-4-one were added at a temperature of ≤0° C., and the reaction medium was allowed to rise to ambient temperature with vigorous stirring for 18 hours. After extracting 3 times with methylene chloride, washing with salt water and drying, 2.49 g of the expected product (translucent crystals) melting at approximately 46-47° C. were obtained.

1. customthe solution obtained
2. customto rise to ambient temperature
3. extractionAfter extracting 3 times with methylene chloride
4. washwashing with salt water
5. customdrying