Diisopropyl Ether → HCID 22118557, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of acetic anhydride (2.7 ml) and formic acid (2.2 ml) was stirring for 30 minutes at 30° C. 2-(2-Amino-5-fluorothiazol-4-yl)-2-(Z)-(hydroxyimino) acetic acid (1.2 g) was added thereto with stirring under ice cooling, and the mixture was stirred for 3 hours at 25 to 35° C. The reaction mixture was poured into an isopropyl ether (50 ml). The resulting precipitate was collected by filtration, dried under reduced pressure to give 2-(5-fluoro-2-formylaminothiazol-4-yl)-2-(Z)-(formyloxyimino)acetic acid (0.65 g).

Provenance & Evidence