Water → HCID 21846511, compound

Participants

Reaction Steps

Potassium carbonate (40 mg) and ethyl bromide (56 mg) were added to a solution of N-(4-pyridyl)-4-tert-butoxycarbonylaminomethyl-2-hydroxybenzamide (100 mg) in dimethylformamide (10 ml), and the mixture was stirred at room temperature for 4 hours. After the reaction, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with water, dried, and concentrated under reduced pressure. The obtained crystals were recrystallized form ethyl acetate-hexane to give 60 mg of N-(4-pyridyl)-4-tert-butoxycarbonylaminomethyl-2-ethoxybenzamide.

Provenance & Evidence