1,4-Dioxane hydrochloride → HCID 86754545, compound

Participants

Reaction Steps

4N Hydrochloric acid-dioxane (1 ml) was added to N-(4-pyridyl)-4-tert-butoxycarbonylaminomethyl-2-ethoxybenzamide (60 mg), and the mixture was stirred at room temperature for 1 hour. After the reaction, the solvent was evaporated under reduced pressure. The obtained crystals were recrystallized from methanol-ethyl acetate to give 40 mg of N-(4-pyridyl)-4-aminomethyl-2-ethoxybenzamide dihydrochloride 1/2 hydrate having a melting point of 251° C. (dec.).

Provenance & Evidence