反应详情

Methyl 4,4-dimethyl-3-oxopentanoate (15.82 g) and guanidine carbonate (20.0 g) were mixed in 80 mL of ethanol, and the solution refluxed for 16 hours. The reaction mixture was concentrated to 50 mL by removal of solvent under reduced pressure, and 20 mL of water was added. The remaining mixture was acidified to pH 5 with acetic acid, affording a white precipitate. The precipitate was collected by filtration, washed with water, and dried in a vacuum oven to give 2-amino-4-hydroxy-6-tert-butylpyrimidine (12.6 g), m.p. 285-288° C. (dec.).

1. temperaturethe solution refluxed for 16 hours
2. concentrationThe reaction mixture was concentrated to 50 mL by removal of solvent under reduced pressure, and 20 mL of water
3. additionwas added
4. customaffording a white precipitate
5. filtrationThe precipitate was collected by filtration
6. washwashed with water
7. customdried in a vacuum oven