HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 619294Generated: October 30, 2026
Carbonic acid-guanidine (1:1) → HCID 15435587, compound
https://huagongshe.com/reaction/619294
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | HCID 21846234 | HCID 21846234 | — |
| Product | HCID 15435587 | HCID 15435587 | 34.7% |
Reaction Steps
1-(4,7-difluoronaphth-1-yl)-4-methylpentane-1,3-dione (0.114 g, 0.5 mmol) was combined with guanidine carbonate (0.180 g, 0.5 mmol) and heated to 150° C. for 6 hours. The reaction was cooled to room temperature and directly purified by column chromatography to give 2-amino-4-(4,7-difluoronaphth-1-yl)-6-isopropylpyrimidine (0.052 g, 34%), m.p. 103-105° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05958934 |
|---|
| Source dataset | uspto-grants-1999_09 |
|---|
| ORD ID | ord-cdeb7158b1114a86874bb4c2cb1eb4c0 |
|---|
| Source note | uspto-grants-1999_09 |
|---|
