Morpholine → HCID 21847035, compound

HRID 619684Notes

Reaction equation

HRID 619684 reaction equation
Cl[CH2:2][C:3]1[C:4]([CH3:13])=[C:5]([C:8]([CH3:12])=[CH:9][C:10]=1[CH3:11])[CH:6]=[O:7].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>C(#N)C>[CH3:12][C:8]1[C:9]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:10]([CH3:11])[C:3]([CH3:2])=[C:4]([CH3:13])[C:5]=1[CH:6]=[O:7]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 14712757HCID 14712757, compound

Product 1

HCID 21847035HCID 21847035, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 0.98 g of 3-chloromethyl-2,4,6-trimethylbenzaldehyde in 20 ml of acetonitrile was treated with 0.87 ml of morpholine. The mixture was stirred at room temperature for 4 hours and thereafter filtered. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was washed twice with water, dried over anhydrous magnesium sulphate and evaporated to dryness. Distillation of the residue yielded 1.05 g of 2,4,6-trimethyl-3-morpholin-4-yl-methylbenzaldenhyde, b.p. 150° C./0.3 Torr.

Workup

  1. filtrationfiltered
  2. customThe solvent was evaporated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washThe solution was washed twice with water
  5. dry with materialdried over anhydrous magnesium sulphate
  6. customevaporated to dryness
  7. distillationDistillation of the residue
  8. customyielded 1.05 g of 2,4,6-trimethyl-3-morpholin-4-yl-methylbenzaldenhyde, b.p. 150° C./0.3 Torr

Sources & evidence

ORD record
ord-9f16f2aa8d5a4ab79b98cf80c9e96be6
Source dataset
uspto-grants-1999_09
Patent number
US05959113

Reaction notes

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