HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57174922, compound → (3S,4R)-3-Amino-4-phenoxyazetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57174922 | HCID 57174922 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (3S,4R)-3-Amino-4-phenoxyazetidin-2-one | HCID 56992325 | 77% |
Reaction Steps
(3S, 4R)-3-benzyloxycarbonylamino-4-phenoxy-azetidin-2-one (1.85 g. 5.9 mmole) is hydrogenated with 2 g of 10% palladium on activated carbon in THF (30 ml) and ethyl acetate (30 ml) at 50 psi hydrogen pressure at room temperature for 2 hours. After removal of catalyst by filtration, 810 mg of deprotected (3S, 4R)-3-amino-4-phenoxy-azetidin-2-one is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05959123 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-a18e4a3b641b4570b9b5c825939a0f40 |
| Source note | uspto-grants-1999_09 |