反应详情

5-Benzoylsulfanylisoquinoline 1.41 g (5.3 mmol) was dissolved in a mixture solution of methanol (50 ml) and chloroform (5 ml), sodium methoxide 500 mg (9.3 mmol) was added, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, the resulting residue was dissolved in DMF 50 ml, 4-nitrofluorobenzene 0.75 g (5.3 mmol) was added, and the mixture was heated and stirred at 100° C. for 3.5 hours. After cooling, water was added to the reaction mixture, the resulting precipitate was collected and washed with water to obtain 5-(4-nitrophenylsulfanyl)isoquinoline 1.36 g (90.9%).

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. dissolutionthe resulting residue was dissolved in DMF 50 ml
4. temperaturethe mixture was heated
5. stirringstirred at 100° C. for 3.5 hours
6. temperatureAfter cooling
7. customthe resulting precipitate was collected
8. washwashed with water