反应详情

4-(5-Isoquinolylsulfonyl)aniline 20 mg (0.1 mmol) was dissolved in a mixture solution of acetic anhydride 2 ml and pyridine 2 ml, the mixture was stirred overnight at room temperature, water was added to the reaction solution, and the solution was extracted with ethyl acetate. The organic layer was washed with saturated potassium hydrogensulfate and with saturated sodium hydrogencarbonate, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide 10 mg (44.3%)

1. extractionthe solution was extracted with ethyl acetate
2. washThe organic layer was washed with saturated potassium hydrogensulfate and with saturated sodium hydrogencarbonate
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure