Potassium Carbonate → HCID 21846964, compound

Participants

Reaction Conditions

Reaction Steps

5-Isoquinolinethiol 500 mg (3.1 mmol) was dissolved in DMF 20 ml, potassium carbonate 1.29 g (9.3 mmol) and N1-(2-amino-4-fluoro-5-nitrophenyl)butane amide 750 mg (3.1 mmol) were added, and the mixture was heated with stirring at 90° C. for 6 hours. The reaction mixture was concentrated under reduced pressure, ethyl acetate-ether was added to the resulting residue to crystallize. The crystals were collected and washed with methanol to obtain N1-[2-amino-4-(5-isoquinolylsulfanyl)-5-nitrophenyl]butanamide 150 mg (12.9%).

Provenance & Evidence