HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 619731Generated: October 26, 2026
Potassium Carbonate → 1-ethyl-6-(5-isoquinolylsulfanyl)-2-methyl-5-nitro-1H-benzo[d]imidazole
https://huagongshe.com/reaction/619731
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Isoquinolinethiol | HCID 11051963 | — |
| Reactant | 6-chloro-1-ethyl-2-methyl-5-nitro-1H-benzo[d]imidazole | HCID 21846946 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-ethyl-6-(5-isoquinolylsulfanyl)-2-methyl-5-nitro-1H-benzo[d]imidazole | HCID 21846962 | 36.3% |
Reaction Steps
5-Isoquinolinethiol 500 mg (3.1 mmol) was dissolved in DMF 20 ml, 6-chloro-1-ethyl-2-methyl-5-nitro-1H-benzo[d]imidazole 910 mg (3.1 mmol) and potassium carbonate 1.29 g (9.3 mmol) were added, and the mixture was stirred for 6 hours at 130° C. The reaction mixture was concentrated under reduced pressure, the residue was crystallized with ethyl acetate, and 1-ethyl-6-(5-isoquinolylsulfanyl)-2-methyl-5-nitro-1H-benzo[d]imidazole 410 mg (35.8%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05959107 |
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| Source dataset | uspto-grants-1999_09 |
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| ORD ID | ord-419f836f31444b5ea88aa33c5bb92832 |
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| Source note | uspto-grants-1999_09 |
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