Water → HCID 21846927, compound

Participants

Reaction Steps

1-Ethyl-5-(5-isoquinolylsulfanyl)-2-methyl-6-nitro-1H-benzo[d]imidazole 300 mg (0.8 mmol) was dissolved in concentrated sulfuric acid 3 ml, Beckmann's reagent (K2Cr2O7 1 g, H2SO4 1 ml, H2O 9 ml) 6 ml was added dropwise, and the mixture was stirred overnight at room temperature. The reaction mixture was neutralized with 4N sodium hydroxide and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and 1-ethyl-5-(5-isoquinolylsulfonyl)-2-methyl-6-nitro-1H-benzo[d]imidazole 70 mg (20.8%) was obtained.

Provenance & Evidence