Potassium Carbonate → HCID 21846993, compound

Participants

Reaction Steps

5-Isoquinolinethiol 250 mg (1.5 mmol) was dissolved in DMF 10 ml, 5-fluoro-2-methyl-6-nitrobenzothiazole 330 mg (1.5 mmol) and potassium carbonate 650 mg (4.7 mmol) were added, and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated under reduced pressure, the residue was crystallized from ether, and 5-(5-isoquinolylsulfanyl)-2-methyl-6-nitrobenzo[d][1,3]thiazole 180 mg (33.1%) was obtained.

Provenance & Evidence