HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 619744Generated: October 25, 2026
2,4,6-Tris((dimethylamino)methyl)phenol → 6-(5-Isoquinolylthio)-7-nitroquinoxaline
https://huagongshe.com/reaction/619744
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,4,6-Tris((dimethylamino)methyl)phenol | HCID 7026 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Isoquinolinethiol | HCID 11051963 | — |
| Reactant | 6-Fluoro-7-nitroquinoxaline | HCID 14362359 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-(5-Isoquinolylthio)-7-nitroquinoxaline | HCID 21846900 | 90.4% |
Reaction Steps
A mixture of 5-isoquinolinethiol 220 mg (1.4 mmol), 6-fluoro-7-nitroquinoxaline 260 mg (1.4 mmol), potassium carbonate 380 mg (2.7 mmol) and DMF 3 ml was stirred for 2 hours at 100° C. The reaction solution was poured into water, the precipitates were collected and washed with water, and 6-(5-isoquinolylthio)-7-nitroquinoxaline 410 mg (90.4%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05959107 |
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| Source dataset | uspto-grants-1999_09 |
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| ORD ID | ord-52a7690e79e14554b80f94ef838aab0a |
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| Source note | uspto-grants-1999_09 |
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