HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-(5-Isoquinolylsulfanyl)-2-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloro-2-nitrobenzonitrile | HCID 100506 | — |
| Reactant | 5-Isoquinolinethiol | HCID 11051963 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(5-Isoquinolylsulfanyl)-2-nitrobenzonitrile | HCID 21846961 | 98.1% |
Reaction Steps
According to the method in Example 10, a mixture of 5-isoquinolinethiol 1.20 g (7.4 mmol), DMF 40 ml, potassium carbonate 2.00 g (14.5 mmol) and 5-chloro-2-nitrobenzonitrile 1.30 g (7.1 mmol) was stirred at room temperature for 2 hours, and 5-(5-isoquinolylsulfanyl)-2-nitrobenzonitrile 2.14 g (97.8%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05959107 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-c3e581ebb9e8443f8c03d75fad2aeae6 |
| Source note | uspto-grants-1999_09 |