HRID619798

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7721

Benzene, 1-(bromomethyl)-4-methyl-

C8H9Br

结构：COc1ccc2ccc(S(=O)(=O)N[C@H]3CCN(Cc4cccc(C#N)c4)C3=O)cc2c1

HCID10550854

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2ccc(S(=O)(=O)N(Cc3ccc(C)cc3)[C@H]3CCN(Cc4cccc(C#N)c4)C3=O)cc2c1

HCID53904932

未命名化合物

PROCEDURE

实验过程

The title compound is prepared as described in EXAMPLE 25, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as described in EXAMPLE 43, part A, and 4-methylbenzyl bromide. The crude product is purified by column chromatography eluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes to afford the title compound as a white foam.

WORKUP

后处理

customThe title compound is prepared
customprepared
customThe crude product is purified by column chromatography
washeluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-88e44902c1ae45f4b38eeaf939bba1e8
来源数据集: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05958918
来源说明: uspto-grants-1999_09

反应 SMILES

[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2].[CH3:32][C:33]1[CH:40]=[CH:39][C:36]([CH2:37]Br)=[CH:35][CH:34]=1>>[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH2:32][C:33]2[CH:40]=[CH:39][C:36]([CH3:37])=[CH:35][CH:34]=2)[S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2]