HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Xylyl bromide → 7-Methoxy-2-napthalenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](3-methylbenzyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Xylyl bromide | HCID 12099 | — |
| Reactant | 7-methoxynaphtalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide | HCID 10550854 | — |
| Product | 7-Methoxy-2-napthalenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl](3-methylbenzyl)amide | HCID 67365848 | — |
Reaction Steps
The title compound is prepared as described in EXAMPLE 25, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as described in EXAMPLE 43, Part A, and 3-methylbenzyl bromide. The crude product is purified by column chromatography eluting with gradient of 40% EtOAc/hexanes to 50% EtOAc/hexanes to afford the title compound as a white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-82ae8516bd3544c8b28157634a121253 |
| Source note | uspto-grants-1999_09 |