Methyl iodide → HCID 54334835, compound

HRID 619801Notes

Reaction equation

HRID 619801 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:30]=[CH:31][CH:32]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[C:18]([F:28])[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:29])#[N:2].[CH3:33]I>>[C:1]([C:3]1[CH:4]=[C:5]([CH:30]=[CH:31][CH:32]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH3:33])[S:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[C:18]([F:28])[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:29])#[N:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 53706388HCID 53706388, compound

Product 1

HCID 54334835HCID 54334835, compound

Procedure

The title compound is prepared as described in EXAMPLE 26, Part A using 2-fluorobiphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide and methyl iodide. The crude product is purified by column chromatography eluting with gradient of 10% EtOAc/CH2Cl2 to 20% EtOAc/CH2Cl2 to afford the title compound as a white foam.

Workup

  1. customThe title compound is prepared
  2. customThe crude product is purified by column chromatography
  3. washeluting with gradient of 10% EtOAc/CH2Cl2 to 20% EtOAc/CH2Cl2

Sources & evidence

ORD record
ord-31268f8fa93a4ffe93083c63020fe677
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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