6-methoxynaphthalene-2-sulfonyl Chloride → HCID 57159997, compound

HRID 619808Notes

Reaction equation

HRID 619808 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].CO[C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[CH:26]=[C:25]([S:30](Cl)(=[O:32])=[O:31])[CH:24]=[CH:23]2>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:30]([C:25]2[CH:24]=[CH:23][C:22]3[CH2:21][CH2:20][CH2:29][CH2:28][C:27]=3[CH:26]=2)(=[O:32])=[O:31])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 106348626-methoxynaphthalene-2-sulfonyl ChlorideHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 57159997HCID 57159997, compound

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B, substituting 5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride for 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with 70% EtOAc/hexanes afford the title compound as a white solid.

Workup

  1. customThe crude product is purified by column chromatography
  2. washeluting with 70% EtOAc/hexanes

Sources & evidence

ORD record
ord-e189ed27143342948361c8d6f7439d8b
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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