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1-benzyl-2-(chloromethyl)-1H-imidazole → 7-Methoxy-2-napthalenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]-(1-benzyl-1H-imidazol-2-ylmethyl)amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-benzyl-2-(chloromethyl)-1H-imidazole | HCID 736792 | — |
| 反応物 | 7-methoxynaphtalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide | HCID 10550854 | — |
| 生成物 | 7-Methoxy-2-napthalenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]-(1-benzyl-1H-imidazol-2-ylmethyl)amide | HCID 86754564 | — |
反応手順
The title compound is prepared as described in EXAMPLE 90, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide, prepared as described in EXAMPLE 43, part A, and 1-benzyl-1H-imidazol-2-ylmethyl chloride. The crude product is purified by column chromatography eluting with 2% MeOH/CH2Cl2 to afford the title compound as a white foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05958918 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-c67c0c024493443e95322b0e1bc3b252 |
| 出典メモ | uspto-grants-1999_09 |