Triethylamine → HCID 67365908, compound

Participants

Reaction Steps

3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride (0.32 g, 1.26 mmol) is suspended in 15 mL of CH3CN. To the solution is added triethylamine (0.384 g, 3.78 mmol) followed by quinoline-6-sulfonyl chloride (0.25 g, 0.99 mmol). After stirring for 1.5 hours, the solution is diluted with EtOAc and washed with 0.1 N aqueous HCl, water and saturated NaCl solution. The organic layer is dried over Na2SO4, filtered and concentrated. The crude residue is purified by column chromatography (4% MeOH/CH2Cl2) to afford the title compound (0.146 g, 0.36 mmol) and as a solid.

Provenance & Evidence