4-(4-Pyridinyl)benzenesulfonyl chloride → HCID 10622617, compound

Participants

Reaction Steps

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride (0.2 g, 0.79 mmol) as in EXAMPLE 24, Part B using 4-pyridin-4-ylbenzene sulfonyl chloride (0.50 g, 1.98 mmol) in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by chromatography (2.5 to 5% MeOH/CH2Cl2) to obtain a white solid (0.25 g, 0.58 mmol).

Provenance & Evidence