3-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride → HCID 54067456, compound

HRID 619827Notes

Reaction equation

HRID 619827 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[Cl:18][C:19]1[C:20]([O:25][C:26]2[CH:31]=[CH:30][C:29]([S:32](Cl)(=[O:34])=[O:33])=[CH:28][CH:27]=2)=[N:21][CH:22]=[CH:23][CH:24]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:32]([C:29]2[CH:30]=[CH:31][C:26]([O:25][C:20]3[C:19]([Cl:18])=[CH:24][CH:23]=[CH:22][N:21]=3)=[CH:27][CH:28]=2)(=[O:34])=[O:33])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochlorideHCID 53867049HCID 53867049, compound

Product 1

HCID 54067456HCID 54067456, compound

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B using 4-(3-chloropyridin-2-yloxy)benzene sulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride.

Sources & evidence

ORD record
ord-463cede251154ab2a1c8d038da7751cb
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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