3-(Bromomethyl)thiophene → HCID 10673806, compound

HRID 619828Notes

Reaction equation

HRID 619828 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([NH:12][S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2].[S:32]1[CH:36]=[CH:35][C:34]([CH2:37]Br)=[CH:33]1>>[C:1]([C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@H:9]([N:12]([CH2:37][C:34]2[CH:35]=[CH:36][S:32][CH:33]=2)[S:13]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[CH:21][CH:22]=3)[CH:17]=2)(=[O:15])=[O:14])[C:8]1=[O:28])#[N:2]

Participants

3

Reactant 2

HCID 5207033-(Bromomethyl)thiopheneHCID 105508547-methoxynaphtalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

Product 1

HCID 10673806HCID 10673806, compound

Procedure

The title compound is prepared as described in EXAMPLE 90, Part A using 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide (0.193 g, 0.44 mmol), prepared as described in EXAMPLE 43, part A, and thiophen-3-ylmethyl bromide (0.30 g, 1.68 mmol). The crude product is triturated with hexane/ether and used without further purification (0.25 g, 0.48 mmol).

Workup

  1. customprepared
  2. customThe crude product is triturated with hexane/ether
  3. customused without further purification (0.25 g, 0.48 mmol)

Sources & evidence

ORD record
ord-3788770e94624b2e982950f5626b4be6
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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