HCID 18392425, compound → HCID 18392424, compound

HRID 619845Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([N:14]([S:19]([C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][C:26]([O:32][CH3:33])=[CH:27][CH:28]=4)[CH:23]=3)(=[O:21])=[O:20])[CH2:15][C:16](O)=[O:17])[C:10]2=[O:34])[S:6][CH:7]=1)#[N:2].C(C1SC=C(CN2CC[C@H](N(CC(O)=O)S(C3C=CC4C(=CC(OC)=CC=4)C=3)(=O)=O)C2=O)C=1)#[N:36]>>[C:1]([C:3]1[CH:4]=[C:5]([CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([N:14]([S:19]([C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][C:26]([O:32][CH3:33])=[CH:27][CH:28]=4)[CH:23]=3)(=[O:21])=[O:20])[CH2:15][C:16]([NH2:36])=[O:17])[C:10]2=[O:34])[S:6][CH:7]=1)#[N:2]

Participants

Reactant 2

HCID 18392425HCID 18392425, compound

HCID 18392431HCID 18392431, compound

Product 1

HCID 18392424HCID 18392424, compound

Procedure

The tiltle compound is prepared as described in EXAMPLE 127, Part C, substituting 2-[[1-(4-cyanothiophene-2-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]-(7-methoxynaphthalene-2-sulfonyl)amino]acetic acid for 2-[[1-(5-cyanothiophene-3-ylmethyl)-2-oxopyrrolidin-3-(S)-yl-(7-methoxynaphthalene-2-sulfonyl)amino]acetic acid. The title compound is obtained as a white foam.

Workup

customThe tiltle compound is prepared

Sources & evidence

ORD record: ord-eb984fa2795f4d2babf428168ed1caeb
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05958918

Reaction notes

Loading…