HRID619846

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Nc1ccc2ccc(S(=O)(=O)Cl)cc2c1)OCc1ccccc1

HCID21845999

未命名化合物

HCID22883629

未命名化合物

PRODUCTS

生成物

结构：N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccc(NC(=O)OCc5ccccc5)cc4c3)C2=O)cs1

HCID18392459

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from 4-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)thiophene-2-carbonitrile hydrochloride as described in EXAMPLE 125, Part C using N-Cbz-7-aminonaphthalene-2-sulfonyl chloride in place of 7-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2 to provide the title compound as a solid.

WORKUP

后处理

customThe crude product is purified by column chromatography
washeluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f1f5562d55f6435c8cf711d8e91a0826
来源数据集: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05958918
来源说明: uspto-grants-1999_09

反应 SMILES

Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([C:14]#[N:15])[S:12][CH:13]=2)[C:4]1=[O:16].[C:17]([NH:27][C:28]1[CH:37]=[C:36]2[C:31]([CH:32]=[CH:33][C:34]([S:38](Cl)(=[O:40])=[O:39])=[CH:35]2)=[CH:30][CH:29]=1)([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18]>>[C:14]([C:11]1[S:12][CH:13]=[C:9]([CH2:8][N:5]2[CH2:6][CH2:7][C@H:3]([NH:2][S:38]([C:34]3[CH:33]=[CH:32][C:31]4[C:36](=[CH:37][C:28]([NH:27][C:17]([O:19][CH2:20][C:21]5[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=5)=[O:18])=[CH:29][CH:30]=4)[CH:35]=3)(=[O:40])=[O:39])[C:4]2=[O:16])[CH:10]=1)#[N:15]