HRID619849

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Nc1ccc2cc(S(=O)(=O)Cl)ccc2c1Cl)OCc1ccccc1

HCID21845700

未命名化合物

HCID22883629

未命名化合物

PRODUCTS

生成物

结构：N#Cc1cc(CN2CC[C@H](NS(=O)(=O)c3ccc4c(Cl)c(NC(=O)OCc5ccccc5)ccc4c3)C2=O)cs1

HCID18392457

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from 4-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)thiophene-2-carbonitrile hydrochloride as described in EXAMPLE 125, Part C using N-Cbz-6-amino-5-chloro-naphthalene-2-sulfonyl chloride in place of 7-methoxynaphthalene-2-sulfonyl chloride. The crude product is concentrated from EtOAc to afford the title compound as a white solid.

WORKUP

后处理

concentrationThe crude product is concentrated from EtOAc

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8912ae64fa154e178b904fbdb290c1e1
来源数据集: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05958918
来源说明: uspto-grants-1999_09

反应 SMILES

Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([C:14]#[N:15])[S:12][CH:13]=2)[C:4]1=[O:16].[C:17]([NH:27][C:28]1[C:29]([Cl:42])=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH:34]=[C:33]([S:38](Cl)(=[O:40])=[O:39])[CH:32]=[CH:31]2)([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18]>>[C:14]([C:11]1[S:12][CH:13]=[C:9]([CH2:8][N:5]2[CH2:6][CH2:7][C@H:3]([NH:2][S:38]([C:33]3[CH:32]=[CH:31][C:30]4[C:35](=[CH:36][CH:37]=[C:28]([NH:27][C:17]([O:19][CH2:20][C:21]5[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=5)=[O:18])[C:29]=4[Cl:42])[CH:34]=3)(=[O:39])=[O:40])[C:4]2=[O:16])[CH:10]=1)#[N:15]