HCID 21845700, compound → HCID 18392457, compound

HRID 619849Notes

Reaction equation

HRID 619849 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([C:14]#[N:15])[S:12][CH:13]=2)[C:4]1=[O:16].[C:17]([NH:27][C:28]1[C:29]([Cl:42])=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH:34]=[C:33]([S:38](Cl)(=[O:40])=[O:39])[CH:32]=[CH:31]2)([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18]>>[C:14]([C:11]1[S:12][CH:13]=[C:9]([CH2:8][N:5]2[CH2:6][CH2:7][C@H:3]([NH:2][S:38]([C:33]3[CH:32]=[CH:31][C:30]4[C:35](=[CH:36][CH:37]=[C:28]([NH:27][C:17]([O:19][CH2:20][C:21]5[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=5)=[O:18])[C:29]=4[Cl:42])[CH:34]=3)(=[O:39])=[O:40])[C:4]2=[O:16])[CH:10]=1)#[N:15]

Participants

3

Reactant 2

HCID 21845700HCID 21845700, compoundHCID 228836294-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride

Product 1

HCID 18392457HCID 18392457, compound

Procedure

The title compound is prepared from 4-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)thiophene-2-carbonitrile hydrochloride as described in EXAMPLE 125, Part C using N-Cbz-6-amino-5-chloro-naphthalene-2-sulfonyl chloride in place of 7-methoxynaphthalene-2-sulfonyl chloride. The crude product is concentrated from EtOAc to afford the title compound as a white solid.

Workup

  1. concentrationThe crude product is concentrated from EtOAc

Sources & evidence

ORD record
ord-8912ae64fa154e178b904fbdb290c1e1
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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