HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)picolinonitrile → [1-(2-Cyano-pyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)picolinonitrile | HCID 10631776 | — |
| Reactant | (S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate | HCID 10750535 | — |
| Product | [1-(2-Cyano-pyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]carbamic acid tert-butyl ester | HCID 10829192 | — |
Reaction Steps
The title compound is prepared from (2-oxopyrrolidin-3-(S)-yl)-carbamic acid tert-butyl ester as described in EXAMPLE 122, Part F using 2-cyano-4-(bromomethyl)pyridine in place of 4-bromomethylthiophene-2-carbonitrile. The crude product is purified by column chromatography eluting with gradient of 25% EtOAc/CH2Cl2 to 50% EtOAc/CH2Cl2 to afford the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958918 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-b8c89eeff8dc46c5a1678e149c6cb36a |
| Source note | uspto-grants-1999_09 |