Methyl iodide → HCID 18392449, compound

HRID 619858Notes

Reaction equation

HRID 619858 reaction equation
[C:1]([C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[CH2:14][CH2:13][C@H:12]([NH:15][S:16]([C:19]3[CH:28]=[CH:27][C:26]4[C:21](=[CH:22][C:23]([O:29][CH3:30])=[CH:24][CH:25]=4)[CH:20]=3)(=[O:18])=[O:17])[C:11]2=[O:31])[CH:6]=[CH:5][N:4]=1)#[N:2].[CH3:32]I>>[C:1]([C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[CH2:14][CH2:13][C@H:12]([N:15]([CH3:32])[S:16]([C:19]3[CH:28]=[CH:27][C:26]4[C:21](=[CH:22][C:23]([O:29][CH3:30])=[CH:24][CH:25]=4)[CH:20]=3)(=[O:18])=[O:17])[C:11]2=[O:31])[CH:6]=[CH:5][N:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10765378HCID 10765378, compound

Product 1

HCID 18392449HCID 18392449, compound

Procedure

The title compound is prepared from 7-methoxynaphthalene-2-sulfonic acid-[1-(2-cyanopyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide as described in EXAMPLE 141, Part D using methyl iodide in place of benzyl bromide. The crude product is purified by column chromatography eluting with gradient of 20% EtOAc/CH2Cl2 to 40% EtOAc/CH2Cl2 to afford the title compound as a white solid.

Workup

  1. customThe crude product is purified by column chromatography
  2. washeluting with gradient of 20% EtOAc/CH2Cl2 to 40% EtOAc/CH2Cl2

Sources & evidence

ORD record
ord-b22d86578b4f48aa8039defb66ded03f
Source dataset
uspto-grants-1999_09
Patent number
US05958918

Reaction notes

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