3-(Bromomethyl)thiophene → 7-methoxy-naphthalene-2-sulfonic acid-[1-(2-cyanothiophene-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]thiophene-3-ylmethylamide

Participants

Reaction Steps

The title compound is prepared from 7-methoxynaphthalene-2-sulfonic acid [1-(2-cyanothiophen-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide (0.5 g, 1.16 mmol) as described in EXAMPLE 126, Part A, using 3-bromomethylthiophene in place of methyl iodide. The crude product is purified by column chromatography eluting with 60% EtOAc/hexanes to afford 7-methoxy-naphthalene-2-sulfonic acid-[1-(2-cyanothiophene-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]thiophene-3-ylmethylamide as a white solid (0.18 g, 0.33 mmol).

Provenance & Evidence