反应详情

7-Methoxynaphthalene-2-sulfonic acid [1-(2-cyanofuran-5-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide is prepared as described in EXAMPLE 125, Part C from of 5-(3-amino-2-oxopyrrolidine-1-ylmethyl)furan-2-carbonitrile hydrochloride (1.1 g, 4.55 mmol), and 7-methoxynaphthalene-2-sulfonyl chloride (1.52 g, 5.9 mmol). After 16 hours, the solution is diluted with CH2Cl2. The organic layer is washed with 0.5 N HCl, water and sat NaCl. The organic layer is dried over Na2SO4, filtered and concentrated. The crude product is purified by column chromatography eluting with 10% EtOAc/CH2Cl2 to afford the title compound (0.88 g, 2.07 mmol) as a white solid.

1. custom7-Methoxynaphthalene-2-sulfonic acid [1-(2-cyanofuran-5-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]amide is prepared
2. washThe organic layer is washed with 0.5 N HCl, water
3. dry with materialThe organic layer is dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe crude product is purified by column chromatography
7. washeluting with 10% EtOAc/CH2Cl2