2-Nitrophenol → 2-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)nitrobenzene

HRID 619971Notes

Reaction equation

HRID 619971 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[N+:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[OH:22])([O-:15])=[O:14]>>[Cl:1][C:2]1[C:3]([O:22][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N+:13]([O-:15])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 69472-NitrophenolHCID 12680753-Chloro-2-fluoro-5-(trifluoromethyl)pyridine

Product 1

HCID 150175302-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)nitrobenzeneYield 63%

Procedure

This material was prepared in 63% yield from 3-chloro-2-fluoro-5-trifluoromethylpyridine and 2-nitrophenol following the general procedure outlined in Example 104. The product was isolated as an amber oil which was characterized by IR and 1H NMR spectroscopy.

Workup

  1. customThe product was isolated as an amber oil which

Sources & evidence

ORD record
ord-42f83e7bb4cd41da96442a7d6bee397e
Source dataset
uspto-grants-1989_04
Patent number
US04818273

Reaction notes

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