HCID 21247868, compound → HCID 21248099, compound

HRID 619986Notes

Reaction equation

HRID 619986 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:15][CH2:14][CH2:13][O:12][CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3]>C(O)C.[Ni]>[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][O:12][CH2:11]2)=[CH:6][CH:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 21247868HCID 21247868, compound

Product 1

HCID 21248099HCID 21248099, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

10 g of 3-p-propylphenyl-4,5-dihydro-6H-pyran (obtainable by hydrolysis of 3-bromotetrahydropyran to give 3-hydroxytetrahydropyran, reaction with p-propylphenyl magnesium bromide to give 3-p-propylphenyl-3-hydroxy-tetrahydropyran followed by dehydration) are dissolved in 100 ml of ethanol and hydrogenated to standstill on 2 g of Raney nickel at 20° under 3 atmospheres. After decantation and evaporation, 3-p-propylphenyltetrahydropyran is obtained.

Workup

  1. customat 20°
  2. customAfter decantation and evaporation

Sources & evidence

ORD record
ord-4692468852cd48ff86f4ee8ea614ff24
Source dataset
uspto-grants-1989_04
Patent number
US04818431

Reaction notes

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