Hydrocarbostyril → 6-(2-Bromopropanoyl)-3,4-dihydroquinolin-2(1H)-one

Participants

Reaction Steps

A mixture of α-bromopropionyl chloride (50 g) in methylene chloride (350 ml) is added to a stirred mixture of 3,4-dihydrocarbostyril (21.8 g) and aluminum chloride (44.8 g). The reaction mixture is stirred under reflux for four hours, poured into an ice water mixture, stirred for 30 minutes and the solid filtered, washed with water, dried, and recrystallized from isopropanol affording the desired product.

Provenance & Evidence