反应详情

The title compound was prepared from 7(3-hydroxypropylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (1.125 g) and acetyl chloride by the general method of Example 4 with the following addition. After removal of solvents under reduced pressure the crude reaction mixture was dissolved in water and brought to pH 9 with 10% sodium hydroxide. The resulting solid was collected and dried before purifying by column chromatography under the conditions used for Example 4. A clear gum was obtained which on trituration with ether gave the title compound as a white solid, m.p. 115°-119° C.

1. customAfter removal of solvents under reduced pressure the crude
2. customreaction mixture
3. customThe resulting solid was collected
4. customdried
5. custombefore purifying by column chromatography under the conditions
6. customA clear gum was obtained which on trituration with ether